ITPKA

Description		inositol-trisphosphate 3-kinase A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Dendritic Spine
	Molecular Function	Inositol Hexakisphosphate Kinase Activity Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Inositol-1,4,5-trisphosphate 3-kinase Activity Kinase Activity Small GTPase Binding
	Biological Process	Inositol Metabolic Process Protein Phosphorylation Signal Transduction Actin Cytoskeleton Organization Inositol Phosphate Biosynthetic Process Phosphatidylinositol Phosphate Biosynthetic Process Regulation Of Synaptic Plasticity Positive Regulation Of Dendritic Spine Morphogenesis Dendritic Spine Maintenance
Pathways		Synthesis of IP3 and IP4 in the cytosol
Drugs		Inositol 1,3,4,5-Tetrakisphosphate 1D-myo-inositol 1,4,5-trisphosphate Phosphoaminophosphonic Acid-Adenylate Ester
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31361310 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 23128233)
Interacting Genes		8 interacting genes: ACTA1 CALM1 CAMK2A CAMK2B ERBB2 ITSN2 PRKACA PRKCA
Entrez ID		3706
HPRD ID		00941
Ensembl ID		ENSG00000137825
Uniprot IDs		P23677
PDB IDs		1W2C 1W2D 1W2F 4UPU
Enriched GO Terms of Interacting Partners?
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