HTR1B

Description		5-hydroxytryptamine receptor 1B
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Calyx Of Held G Protein-coupled Serotonin Receptor Complex Integral Component Of Presynaptic Membrane Serotonergic Synapse
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	G Protein-coupled Receptor Internalization G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Gamma-aminobutyric Acid Secretion Regulation Of Dopamine Secretion Negative Regulation Of Serotonin Secretion Negative Regulation Of Synaptic Transmission, GABAergic Response To Cocaine Vasoconstriction Drinking Behavior Response To Ethanol Bone Remodeling Regulation Of Behavior Response To Mineralocorticoid Negative Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Alkaloid Cellular Response To Xenobiotic Stimulus Cellular Response To Temperature Stimulus Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Synaptic Vesicle Exocytosis
Pathways		Serotonin receptors G alpha (i) signalling events
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Amoxapine Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Ondansetron Almotriptan Naratriptan Rizatriptan Pindolol Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Penbutolol Yohimbine Dapoxetine NXN-188 Pizotifen Asenapine Bopindolol Vortioxetine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Early chronic obstructive pulmonary disease in never smokers ( 33235445) HDL cholesterol levels in HIV infection ( 33109212) Psychological distress ( 30705256) Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		4 interacting genes: ACTN2 HTR1A HTR1D MDFI
Entrez ID		3351
HPRD ID		01634
Ensembl ID		ENSG00000135312
Uniprot IDs		A8K215 P28222 X5D7I5
PDB IDs		2G1X 4IAQ 4IAR 5V54 6G79 7C61
Enriched GO Terms of Interacting Partners?
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