TAB3

Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Autophagy Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS
Interacting Genes		10 interacting genes: CEP57L1 IKBKG MAP3K7CL OGT PIN1 PPIL3 STAT3 TAB1 TRAF2 TRAF6
Entrez ID		257397
HPRD ID		06738
Ensembl ID		ENSG00000157625
Uniprot IDs		Q8N5C8
PDB IDs
Enriched GO Terms of Interacting Partners?
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