TPCN2

Description		two pore segment channel 2
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Endosome Membrane Integral Component Of Membrane Endolysosome Membrane
	Molecular Function	Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity Protein Kinase Binding Identical Protein Binding NAADP-sensitive Calcium-release Channel Activity Phosphatidylinositol-3,5-bisphosphate Binding Intracellular Phosphatidylinositol-3,5-bisphosphate-sensitive Cation Channel Activity
	Biological Process	Cellular Calcium Ion Homeostasis Smooth Muscle Contraction Lysosome Organization Regulation Of Autophagy Regulation Of Exocytosis Receptor-mediated Endocytosis Of Virus By Host Cell Calcium-mediated Signaling Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Endocytosis Involved In Viral Entry Into Host Cell Endosome To Lysosome Transport Of Low-density Lipoprotein Particle
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Blond vs non-blond hair color ( 26184321) Blond vs. brown hair color ( 18488028) Blond vs. brown/black hair color ( 30531825) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cadmium levels ( 26025379) Cutaneous malignant melanoma ( 26237428) Estimated glomerular filtration rate ( 31152163 31015462) Hair color ( 29662168) Heel bone mineral density ( 30598549 28869591) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Nevus count or cutaneous melanoma ( 30429480) Systemic lupus erythematosus ( 33272962) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		1 interacting genes: ADRA1A
Entrez ID		219931
HPRD ID		18218
Ensembl ID		ENSG00000162341
Uniprot IDs		Q59G56 Q8NHX9
PDB IDs		6NQ0 6NQ1 6NQ2
Enriched GO Terms of Interacting Partners?
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