FAP

Description		fibroblast activation protein alpha
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Lamellipodium Lamellipodium Membrane Ruffle Membrane Apical Part Of Cell Basal Part Of Cell Peptidase Complex
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Proteolysis Cell Adhesion Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Endothelial Cell Migration Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Cycle Regulation Of Fibrinolysis Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Melanocyte Proliferation Positive Regulation Of Execution Phase Of Apoptosis Melanocyte Apoptotic Process Negative Regulation Of Extracellular Matrix Organization
Pathways
Drugs		Sibrotuzumab
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Inflammatory skin disease ( 25574825) Medication use (thyroid preparations) ( 31015401) Regular attendance at a pub or social club ( 29970889) Systemic lupus erythematosus ( 33272962 28714469)
Interacting Genes		4 interacting genes: DPP4 EPC2 NR4A2 PLAUR
Entrez ID		2191
HPRD ID		02674
Ensembl ID		ENSG00000078098
Uniprot IDs		B4DLR2 Q12884
PDB IDs		1Z68 6Y0F
Enriched GO Terms of Interacting Partners?
Tagcloud ?