DNA2

Description		DNA replication helicase/nuclease 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Nucleoid
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Nuclease Activity Protein Binding ATP Binding ATP Hydrolysis Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base 5'-flap Endonuclease Activity Single-stranded DNA Helicase Activity 5'-3' DNA Helicase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Replication Checkpoint Signaling Telomere Maintenance DNA Double-strand Break Processing DNA Replication Mitochondrial DNA Replication Base-excision Repair Telomere Maintenance Via Semi-conservative Replication DNA Duplex Unwinding DNA Replication, Okazaki Fragment Processing DNA Replication, Removal Of RNA Primer Mitochondrial DNA Repair G-quadruplex DNA Unwinding Positive Regulation Of DNA Replication Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis T-circle Formation Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways		Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: BLM RBBP8 TRAF6
Entrez ID		1763
HPRD ID		19123
Ensembl ID		ENSG00000138346
Uniprot IDs		P51530
PDB IDs		5EAY
Enriched GO Terms of Interacting Partners?
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