NQO1

Description		NAD(P)H quinone dehydrogenase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Neuronal Cell Body Synapse
	Molecular Function	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Superoxide Dismutase Activity Protein Binding NADPH Dehydrogenase (quinone) Activity Identical Protein Binding NADH Dehydrogenase (quinone) Activity
	Biological Process	Response To Ischemia NADH Oxidation Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Aging Response To Nutrient Response To Xenobiotic Stimulus Response To Toxic Substance Response To Hormone Response To Carbohydrate Response To Amine Removal Of Superoxide Radicals Response To Estradiol Response To Testosterone Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Response To Ethanol Response To Electrical Stimulus Cellular Response To Hydrogen Peroxide NADPH Oxidation Cellular Response To Metal Ion Response To Tetrachloromethane Response To L-glutamine Response To Hydrogen Sulfide Response To Flavonoid
Pathways		Regulation of ornithine decarboxylase (ODC)
Drugs		Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Triglyceride levels ( 32203549)
Interacting Genes		12 interacting genes: CDC42 CDH16 CDH5 DNAJB1 GALT HIF1A HSPA1A ING1 PRKN STUB1 TP53 UBE2D1
Entrez ID		1728
HPRD ID		00518
Ensembl ID		ENSG00000181019
Uniprot IDs		B4DLR8 P15559
PDB IDs		1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4 6LLC
Enriched GO Terms of Interacting Partners?
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