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CX3CR1
Description
C-X3-C motif chemokine receptor 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Neuronal Cell Body Membrane
Neuron Projection
Perinuclear Region Of Cytoplasm
Dendritic Tree
Molecular Function
G Protein-coupled Receptor Activity
Chemokine Receptor Activity
Protein Binding
G Protein-coupled Peptide Receptor Activity
C-C Chemokine Receptor Activity
C-X3-C Chemokine Receptor Activity
C-C Chemokine Binding
C-X3-C Chemokine Binding
CX3C Chemokine Receptor Binding
Biological Process
Positive Regulation Of Neuroblast Proliferation
Adaptive Immune Response
Microglial Cell Activation Involved In Immune Response
Response To Ischemia
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Brain Development
Memory
Response To Wounding
Calcium-mediated Signaling
Central Nervous System Maturation
Negative Regulation Of Cell Migration
Leukocyte Chemotaxis
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Interleukin-1 Beta Production
Social Behavior
Autocrine Signaling
Innate Immune Response
Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Angiogenesis
Regulation Of Synaptic Plasticity
Host-mediated Regulation Of Intestinal Microbiota Composition
Regulation Of Neurogenesis
Positive Regulation Of Neurogenesis
Modulation Of Chemical Synaptic Transmission
Leukocyte Tethering Or Rolling
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Synapse Maturation
Cell Chemotaxis
Antifungal Innate Immune Response
Chemokine-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Monocyte Chemotaxis
Synapse Pruning
Negative Regulation Of Hippocampal Neuron Apoptotic Process
Multiple Spine Synapse Organization, Single Dendrite
Negative Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of I-kappaB Phosphorylation
Regulation Of Microglial Cell Migration
Positive Regulation Of Microglial Cell Migration
Negative Regulation Of Microglial Cell Mediated Cytotoxicity
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
34315874
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Aspartate aminotransferase levels (
34315874
)
Autoimmune thyroid disease (
32581359
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Daytime sleep phenotypes (
27126917
)
Granulocyte percentage of myeloid white cells (
27863252
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
2 interacting genes:
CCDC167
CX3CL1
Entrez ID
1524
HPRD ID
03277
Ensembl ID
ENSG00000168329
Uniprot IDs
P49238
PDB IDs
Enriched GO Terms of Interacting Partners
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