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AP2S1

Description adaptor related protein complex 2 subunit sigma 1
Image
GO Annotations Cellular Component
  • Cytosol
  • Plasma Membrane
  • AP-2 Adaptor Complex
  • Endocytic Vesicle Membrane
  • Clathrin-coated Endocytic Vesicle Membrane
  • Endolysosome Membrane
  • Intracellular Membrane-bounded Organelle
  • Clathrin-coated Endocytic Vesicle
Molecular Function
  • Protein Binding
  • Clathrin Adaptor Activity
Biological Process
  • Intracellular Protein Transport
  • Vesicle-mediated Transport
  • Regulation Of Endocytosis
  • Clathrin Coat Assembly
  • Clathrin-dependent Endocytosis
Pathways
  • Nef Mediated CD4 Down-regulation
  • Retrograde neurotrophin signalling
  • Retrograde neurotrophin signalling
  • Nef Mediated CD8 Down-regulation
  • MHC class II antigen presentation
  • EPH-ephrin mediated repulsion of cells
  • Recycling pathway of L1
  • Recycling pathway of L1
  • WNT5A-dependent internalization of FZD4
  • WNT5A-dependent internalization of FZD2, FZD5 and ROR2
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • VLDLR internalisation and degradation
  • LDL clearance
  • Potential therapeutics for SARS
Drugs
Diseases
GWAS
  • Brain morphology (MOSTest) ( 32665545)
  • Deep white matter hyperintensities ( 32517579)
  • Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes 6 interacting genes: AAGAB AP2A1 AP2B1 RNF41 TDGF1 UBC
Entrez ID 1175
HPRD ID 03762
Ensembl ID ENSG00000042753
Uniprot IDs M0QYZ2 M0R0N4 P53680 X6R390
PDB IDs 6URI
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025