SP140

Description		SP140 nuclear body protein
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Mitochondrion PML Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Defense Response
Pathways
Drugs
Diseases
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 18758461 28165464 24292274 23770605) Crohn's disease ( 28067908 21102463 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of granulocytes ( 27863252) Night sleep phenotypes ( 27126917) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		3 interacting genes: EIF4E2 NFE2L2 SIRT2
Entrez ID		11262
HPRD ID		09780
Ensembl ID		ENSG00000079263
Uniprot IDs		B4DVW8 Q0VGE4 Q13342 Q8IWJ1
PDB IDs		2MD7 2MD8 6G8R
Enriched GO Terms of Interacting Partners?
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