ADCY3

Description		adenylate cyclase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Membrane Integral Component Of Membrane Ciliary Membrane
	Molecular Function	Adenylate Cyclase Activity Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	CAMP Biosynthetic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Single Fertilization Acrosome Reaction Sensory Perception Of Smell Olfactory Learning Flagellated Sperm Motility Intracellular Signal Transduction Cellular Response To Forskolin
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 2 years old ( 31575865) BMI at 3 years old ( 31575865) BMI at 5 years old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 28552196 22344219 29381148 26426971 26961502 24861553 31453325 28892062 25673413 20935630 29273807 23583978 28448500 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in non-asthmatics ( 23517042) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 29059683) Childhood body mass index ( 33045005 26604143) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronotype ( 30696823) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Dentures ( 31235808) Diastolic blood pressure ( 28135244 27841878 30578418) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340 18391951) Height adjusted BMI ( 25044758) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 31453325 25673412) Hip circumference adjusted for BMI ( 34021172) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 30677029) Pubertal anthropometrics ( 23449627) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 32888494 27863252) Systolic blood pressure ( 27841878 30578418) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: CAMK2G MTNR1B STOML3
Entrez ID		109
HPRD ID		02620
Ensembl ID		ENSG00000138031
Uniprot IDs		A0A0A0MSC1 B7ZLX9 O60266
PDB IDs
Enriched GO Terms of Interacting Partners?
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