Pulmonary - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 2 Hide
BAD and SFN	BCL2 associated agonist of cell death	stratifin	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors	Navitoclax
BAG1 and MAPT	BAG cochaperone 1	microtubule associated protein tau	Regulation of HSF1-mediated heat shock response	Caspase-mediated cleavage of cytoskeletal proteins	(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Lansoprazole Astemizole Paclitaxel Docetaxel	Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome
BAG1 and HSPA4	BAG cochaperone 1	heat shock protein family A (Hsp70) member 4	Regulation of HSF1-mediated heat shock response	Regulation of HSF1-mediated heat shock response	(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol	Phenethyl Isothiocyanate
ADGRB1 and ELMO1	adhesion G protein-coupled receptor B1	engulfment and cell motility 1		Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
ADGRB1 and PDZD2	adhesion G protein-coupled receptor B1	PDZ domain containing 2
ADGRB3 and ELMO1	adhesion G protein-coupled receptor B3	engulfment and cell motility 1		Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
BAK1 and HSPD1	BCL2 antagonist/killer 1	heat shock protein family D (Hsp60) member 1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation		Copper	Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
BAK1 and BCL2L10	BCL2 antagonist/killer 1	BCL2 like 10	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria
BAK1 and NFKBIB	BCL2 antagonist/killer 1	NFKB inhibitor beta	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation
BAK1 and MFN1	BCL2 antagonist/killer 1	mitofusin 1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Pink/Parkin Mediated Mitophagy Factors involved in megakaryocyte development and platelet production
BAK1 and BAX	BCL2 antagonist/killer 1	BCL2 associated X, apoptosis regulator	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 NTRK3 as a dependence receptor			Colorectal cancer
BAK1 and ERN1	BCL2 antagonist/killer 1	endoplasmic reticulum to nucleus signaling 1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	IRE1alpha activates chaperones IRE1alpha activates chaperones		N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
BAK1 and MCL1	BCL2 antagonist/killer 1	MCL1 apoptosis regulator, BCL2 family member	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Interleukin-4 and Interleukin-13 signaling
BAK1 and BCL2	BCL2 antagonist/killer 1	BCL2 apoptosis regulator	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling		Ibuprofen Paclitaxel Docetaxel Rasagiline S-8184 Paclitaxel docosahexaenoic acid Glycine betaine Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax	Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
BAK1 and BCL2A1	BCL2 antagonist/killer 1	BCL2 related protein A1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria
BAK1 and BCL2L1	BCL2 antagonist/killer 1	BCL2 like 1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome		4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Gossypol
BAK1 and DBN1	BCL2 antagonist/killer 1	drebrin 1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria
BAK1 and HSD17B4	BCL2 antagonist/killer 1	hydroxysteroid 17-beta dehydrogenase 4	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins		NADH 3r-Hydroxydecanoyl-Coa	Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
BAK1 and TP53	BCL2 antagonist/killer 1	tumor protein p53	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription Regulation of PTEN gene transcription Factors involved in megakaryocyte development and platelet production		Acetylsalicylic acid Zinc Triethyl Phosphate AZD 3355 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine	Osteosarcoma Adrenal carcinoma Thyroid cancer Breast cancer Basal cell carcinoma Malignant melanoma Pancreatic cancer Gastric cancer Malignant pleural mesothelioma Non-small cell lung cancer Esophageal cancer Oral cancer Multiple myeloma Small cell lung cancer Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL) Glioma Squamous cell carcinoma Kaposi's sarcoma Cholangiocarcinoma Gallbladder cancer Cancer of the anal canal Hepatocellular carcinoma Choriocarcinoma Vulvar cancer Choroid plexus papilloma Burkitt lymphoma Adult T-cell leukemia Hairy-cell leukemia Bladder cancer Chronic lymphocytic leukemia (CLL) Penile cancer Endometrial Cancer Ovarian cancer Colorectal cancer Laryngeal cancer Chronic myeloid leukemia (CML)
BAK1 and VDAC1	BCL2 antagonist/killer 1	voltage dependent anion channel 1	Activation and oligomerization of BAK protein Release of apoptotic factors from the mitochondria	Mitochondrial protein import Pink/Parkin Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport		Aluminium monostearate

Search Results for: Pulmonary