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Search Results for: Pulmonary

5304 interactions found:

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Drugs 2
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Diseases 2
ARNTL and KAT2B aryl hydrocarbon receptor nuclear translocator like lysine acetyltransferase 2B
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Pre-NOTCH Transcription and Translation
  • Pre-NOTCH Transcription and Translation
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
  • NOTCH1 Intracellular Domain Regulates Transcription
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • HATs acetylate histones
  • Notch-HLH transcription pathway
  • B-WICH complex positively regulates rRNA expression
  • Physiological factors
  • Metalloprotease DUBs
  • RNA Polymerase I Transcription Initiation
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX3 regulates NOTCH signaling
  • RUNX3 regulates NOTCH signaling
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH4 Intracellular Domain Regulates Transcription
  • Estrogen-dependent gene expression
  • Regulation of FOXO transcriptional activity by acetylation
  • Coenzyme A
  • (3E)-4-(1-METHYL-1H-INDOL-3-YL)BUT-3-EN-2-ONE
  • N-(3-AMINOPROPYL)-2-NITROBENZENAMINE
ARNTL and PER3 aryl hydrocarbon receptor nuclear translocator like period circadian regulator 3
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
ARNTL and UBE2I aryl hydrocarbon receptor nuclear translocator like ubiquitin conjugating enzyme E2 I
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Meiotic synapsis
  • Vitamin D (calciferol) metabolism
  • SUMO is transferred from E1 to E2 (UBE2I, UBC9)
  • SUMO is transferred from E1 to E2 (UBE2I, UBC9)
  • SUMOylation of DNA damage response and repair proteins
  • SUMO E3 ligases SUMOylate target proteins
  • SUMOylation of transcription factors
  • SUMOylation of transcription factors
  • SUMOylation of ubiquitinylation proteins
  • SUMOylation of transcription cofactors
  • SUMOylation of transcription cofactors
  • SUMOylation of SUMOylation proteins
  • SUMOylation of intracellular receptors
  • SUMOylation of intracellular receptors
  • SUMOylation of chromatin organization proteins
  • SUMOylation of chromatin organization proteins
  • SUMOylation of RNA binding proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA methylation proteins
  • SUMOylation of DNA methylation proteins
  • SUMOylation of immune response proteins
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Processing of DNA double-strand break ends
  • Formation of Incision Complex in GG-NER
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Postmitotic nuclear pore complex (NPC) reformation
ARNTL and CRY1 aryl hydrocarbon receptor nuclear translocator like cryptochrome circadian regulator 1
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Circadian Clock
ARNTL and NPAS2 aryl hydrocarbon receptor nuclear translocator like neuronal PAS domain protein 2
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Circadian Clock
ARNTL and RARA aryl hydrocarbon receptor nuclear translocator like retinoic acid receptor alpha
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Nuclear Receptor transcription pathway
  • SUMOylation of intracellular receptors
  • Signaling by Retinoic Acid
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Transcriptional regulation of granulopoiesis
  • Transcriptional regulation of granulopoiesis
  • Adapalene
  • Acitretin
  • Alitretinoin
  • Tretinoin
  • Tazarotene
  • Etretinate
  • Isotretinoin
  • Tamibarotene
  • LGD-1550
  • Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
  • Acute myeloid leukemia (AML)
ARNTL and DELEC1 aryl hydrocarbon receptor nuclear translocator like deleted in esophageal cancer 1
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
ARNTL and CLOCK aryl hydrocarbon receptor nuclear translocator like clock circadian regulator
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • HATs acetylate histones
  • Circadian Clock
ARNTL and BHLHE40 aryl hydrocarbon receptor nuclear translocator like basic helix-loop-helix family member e40
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
ARNTL and SIRT1 aryl hydrocarbon receptor nuclear translocator like sirtuin 1
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Regulation of HSF1-mediated heat shock response
  • Circadian Clock
  • SIRT1 negatively regulates rRNA expression
  • SIRT1 negatively regulates rRNA expression
  • Regulation of FOXO transcriptional activity by acetylation
  • Regulation of FOXO transcriptional activity by acetylation
  • SRT501
ARNTL and RHOU aryl hydrocarbon receptor nuclear translocator like ras homolog family member U
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Rho GTPase cycle
  • Interleukin-4 and Interleukin-13 signaling
ARNTL and CSNK1E aryl hydrocarbon receptor nuclear translocator like casein kinase 1 epsilon
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • WNT mediated activation of DVL
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Circadian Clock
  • Anchoring of the basal body to the plasma membrane
  • Major pathway of rRNA processing in the nucleolus and cytosol
  • AURKA Activation by TPX2
ARNTL and EP300 aryl hydrocarbon receptor nuclear translocator like E1A binding protein p300
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Regulation of gene expression by Hypoxia-inducible Factor
  • RORA activates gene expression
  • RORA activates gene expression
  • Polo-like kinase mediated events
  • Pre-NOTCH Transcription and Translation
  • Pre-NOTCH Transcription and Translation
  • PPARA activates gene expression
  • Formation of the beta-catenin:TCF transactivating complex
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
  • NOTCH1 Intracellular Domain Regulates Transcription
  • NOTCH1 Intracellular Domain Regulates Transcription
  • NOTCH2 intracellular domain regulates transcription
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
  • HATs acetylate histones
  • Attenuation phase
  • Transcriptional regulation of white adipocyte differentiation
  • Transcriptional regulation of white adipocyte differentiation
  • SUMOylation of transcription cofactors
  • Circadian Clock
  • Circadian Clock
  • B-WICH complex positively regulates rRNA expression
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • CD209 (DC-SIGN) signaling
  • Metalloprotease DUBs
  • Formation of TC-NER Pre-Incision Complex
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER)
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
  • Regulation of TP53 Activity through Acetylation
  • Regulation of TP53 Activity through Methylation
  • PI5P Regulates TP53 Acetylation
  • Activation of the TFAP2 (AP-2) family of transcription factors
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • RUNX3 regulates NOTCH signaling
  • RUNX3 regulates NOTCH signaling
  • Regulation of RUNX3 expression and activity
  • RUNX3 regulates p14-ARF
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH4 Intracellular Domain Regulates Transcription
  • Estrogen-dependent gene expression
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • TRAF3-dependent IRF activation pathway
  • TRAF6 mediated IRF7 activation
  • FOXO-mediated transcription of cell death genes
  • Transcriptional regulation of granulopoiesis
  • Transcriptional regulation of granulopoiesis
  • Regulation of FOXO transcriptional activity by acetylation
  • Regulation of FOXO transcriptional activity by acetylation
  • Rubinstein-Taybi syndrome
ARNTL and EPAS1 aryl hydrocarbon receptor nuclear translocator like endothelial PAS domain protein 1
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
  • Regulation of gene expression by Hypoxia-inducible Factor
  • Cellular response to hypoxia
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • Transcriptional regulation of pluripotent stem cells
  • PTK6 Expression
  • Neddylation
  • Pexophagy
  • Congenital polycythemia; Familial erythrocytosis (ECYT)
ARNTL and NPAS4 aryl hydrocarbon receptor nuclear translocator like neuronal PAS domain protein 4
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • Circadian Clock
ARRB1 and HCK arrestin beta 1 HCK proto-oncogene, Src family tyrosine kinase
  • Activated NOTCH1 Transmits Signal to the Nucleus
  • G alpha (s) signalling events
  • Lysosome Vesicle Biogenesis
  • Golgi Associated Vesicle Biogenesis
  • Thrombin signalling through proteinase activated receptors (PARs)
  • Activation of SMO
  • Activation of SMO
  • MAP2K and MAPK activation
  • Ub-specific processing proteases
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • Signaling downstream of RAS mutants
  • Nef and signal transduction
  • FCGR activation
  • Regulation of signaling by CBL
  • Regulation of signaling by CBL
  • FLT3 Signaling
  • FCGR3A-mediated IL10 synthesis
  • FCGR3A-mediated phagocytosis
  • 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
  • Phosphonotyrosine
  • Quercetin
  • Bosutinib
ARSA and BMPR2 arylsulfatase A bone morphogenetic protein receptor type 2
  • Glycosphingolipid metabolism
  • The activation of arylsulfatases
  • Neutrophil degranulation
  • Signaling by BMP
  • N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium
  • 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid
  • Metachromatic leukodystrophy (MLD)
ASGR1 and HSP90AA1 asialoglycoprotein receptor 1 heat shock protein 90 alpha family class A member 1
  • Asparagine N-linked glycosylation
  • Signaling by ERBB2
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
  • Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
  • vRNP Assembly
  • Regulation of actin dynamics for phagocytic cup formation
  • eNOS activation
  • Regulation of PLK1 Activity at G2/M Transition
  • Scavenging by Class F Receptors
  • Scavenging by Class F Receptors
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • HSF1 activation
  • Attenuation phase
  • HSF1-dependent transactivation
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Sema3A PAK dependent Axon repulsion
  • VEGFA-VEGFR2 Pathway
  • VEGFA-VEGFR2 Pathway
  • VEGFR2 mediated vascular permeability
  • Uptake and function of diphtheria toxin
  • PIWI-interacting RNA (piRNA) biogenesis
  • Anchoring of the basal body to the plasma membrane
  • Constitutive Signaling by EGFRvIII
  • Interleukin-4 and Interleukin-13 signaling
  • Neutrophil degranulation
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • AURKA Activation by TPX2
  • Downregulation of ERBB2 signaling
  • ESR-mediated signaling
  • Extra-nuclear estrogen signaling
  • Estrogen-dependent gene expression
  • Chaperone Mediated Autophagy
  • Constitutive Signaling by Overexpressed ERBB2
  • Aggrephagy
  • Drug-mediated inhibition of ERBB2 signaling
  • Signaling by ERBB2 KD Mutants
  • Resistance of ERBB2 KD mutants to trastuzumab
  • Resistance of ERBB2 KD mutants to sapitinib
  • Resistance of ERBB2 KD mutants to tesevatinib
  • Resistance of ERBB2 KD mutants to neratinib
  • Resistance of ERBB2 KD mutants to osimertinib
  • Resistance of ERBB2 KD mutants to afatinib
  • Resistance of ERBB2 KD mutants to AEE788
  • Resistance of ERBB2 KD mutants to lapatinib
  • Signaling by ERBB2 ECD mutants
  • Signaling by ERBB2 TMD/JMD mutants
  • Drug resistance in ERBB2 TMD/JMD mutants
  • Rifabutin
  • Nedocromil
  • 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine
  • Geldanamycin
  • 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
  • 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
  • 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid
  • 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
  • 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine
  • 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine
  • 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole
  • 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine
  • 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine
  • 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
  • Quercetin
  • 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine
  • 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
  • N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
  • Tanespimycin
  • SNX-5422
  • N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
  • 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
  • 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE
  • 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
  • 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
  • 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
  • 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
  • (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one
  • 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE
  • 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE
  • N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
  • 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
  • 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol
  • 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL
  • 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol
  • 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
  • 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine
  • (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime
  • 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-
  • 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
  • 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol
  • 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
  • 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine
  • 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine
  • 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE
  • 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
  • Copper
  • Alvespimycin
GET3 and SEC61A1 guided entry of tail-anchored proteins factor 3, ATPase SEC61 translocon subunit alpha 1
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • ER-Phagosome pathway
  • SRP-dependent cotranslational protein targeting to membrane
  • ATP
KCTD14 and NARS2 potassium channel tetramerization domain containing 14 asparaginyl-tRNA synthetase 2, mitochondrial
  • Mitochondrial tRNA aminoacylation
  • L-Asparagine

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