Respiratory - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 2 Hide
ADH5 and CSNK2B	alcohol dehydrogenase 5 (class III), chi polypeptide	casein kinase 2 beta	Ethanol oxidation	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	NADH Lauric Acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione	ATP Quercetin
ADH5 and ESRRA	alcohol dehydrogenase 5 (class III), chi polypeptide	estrogen related receptor alpha	Ethanol oxidation	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	NADH Lauric Acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione	Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
ADH5 and PRDX1	alcohol dehydrogenase 5 (class III), chi polypeptide	peroxiredoxin 1	Ethanol oxidation	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	NADH Lauric Acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione	Zinc Copper Artenimol
ADH5 and APP	alcohol dehydrogenase 5 (class III), chi polypeptide	amyloid beta precursor protein	Ethanol oxidation	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	NADH Lauric Acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Phenserine Tiomolibdate ion CAD106 Mito-4509 Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F)	Alzheimer's disease (AD)
ADH5 and SNTA1	alcohol dehydrogenase 5 (class III), chi polypeptide	syntrophin alpha 1	Ethanol oxidation		NADH Lauric Acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
ADH5 and CHD3	alcohol dehydrogenase 5 (class III), chi polypeptide	chromodomain helicase DNA binding protein 3	Ethanol oxidation	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	NADH Lauric Acid 12-Hydroxydodecanoic Acid S-Hydroxymethyl Glutathione
ADH6 and ARRB1	alcohol dehydrogenase 6 (class V)	arrestin beta 1	Ethanol oxidation	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants
ADM and EDN1	adrenomedullin	endothelin 1	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (q) signalling events		TBC-3711
ADORA1 and SNF8	adenosine A1 receptor	SNF8 subunit of ESCRT-II	Adenosine P1 receptors G alpha (i) signalling events	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline
ADORA1 and P2RY1	adenosine A1 receptor	purinergic receptor P2Y1	Adenosine P1 receptors G alpha (i) signalling events	G alpha (q) signalling events P2Y receptors ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline
ADORA1 and ATXN1L	adenosine A1 receptor	ataxin 1 like	Adenosine P1 receptors G alpha (i) signalling events		Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline
ADORA1 and GNAI2	adenosine A1 receptor	G protein subunit alpha i2	Adenosine P1 receptors G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline		Adrenal carcinoma
ADORA1 and DRD1	adenosine A1 receptor	dopamine receptor D1	Adenosine P1 receptors G alpha (i) signalling events	Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline	Ziprasidone Cabergoline Cabergoline Ropinirole Olanzapine Olanzapine Methylergometrine Clozapine Mirtazapine Thiethylperazine Phenylpropanolamine Loxapine Loxapine Pramipexole Promazine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Mianserin Asenapine Quinagolide Tetrahydropalmatine Dihydrexidine
ADORA1 and EPB41L2	adenosine A1 receptor	erythrocyte membrane protein band 4.1 like 2	Adenosine P1 receptors G alpha (i) signalling events	Neurexins and neuroligins	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline
ADORA1 and GNAO1	adenosine A1 receptor	G protein subunit alpha o1	Adenosine P1 receptors G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline
ADORA1 and GNAS	adenosine A1 receptor	GNAS complex locus	Adenosine P1 receptors G alpha (i) signalling events	Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy Pseudohypoparathyroidism Progressive osseous heteroplasia (POH)
ADORA1 and GNAZ	adenosine A1 receptor	G protein subunit alpha z	Adenosine P1 receptors G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding ADORA2B mediated anti-inflammatory cytokines production	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline
ADORA1 and GRM1	adenosine A1 receptor	glutamate metabotropic receptor 1	Adenosine P1 receptors G alpha (i) signalling events	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins	Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Enprofylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide Tecadenoson Naxifylline Tonapofylline Rolofylline	Glutamic Acid 4-(1-Amino-1-Carboxy-Ethyl)-Benzoic Acid
PARP1 and NRF1	poly(ADP-ribose) polymerase 1	nuclear respiratory factor 1	POLB-Dependent Long Patch Base Excision Repair Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Theophylline Zinc Carba-Nicotinamide-Adenine-Dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Niraparib Rucaparib
ADRA2A and YWHAZ	adrenoceptor alpha 2A	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors	Amphetamine Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Dipivefrin Prazosin Chlorpromazine Brimonidine Nortriptyline Amoxapine Amoxapine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Trimipramine Risperidone Epinastine Tolazoline Fenoldopam Dobutamine Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Carvedilol Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Methamphetamine Propericiazine Zuclopenthixol Dronedarone Lofexidine Epicept NP-1 Mianserin Asenapine Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Lurasidone Dosulepin Etoperidone Cirazoline Moxonidine Setiptiline Rilmenidine Tiapride	Phenethyl Isothiocyanate

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