Respiratory - Wiki-CORONA

Symbols	Name 1	Name 2	Pathways 1 Hide	Pathways 2 Hide	Drugs 1 Hide	Drugs 2 Hide	Diseases 1 Hide	Diseases 2 Hide
MEOX2 and MT-CO1	mesenchyme homeobox 2	cytochrome c oxidase subunit I		TP53 Regulates Metabolic Genes Respiratory electron transport		Cholic Acid N-Formylmethionine Oxygen		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MEOX2 and MT-ND1	mesenchyme homeobox 2	NADH dehydrogenase, subunit 1 (complex I)		Respiratory electron transport Complex I biogenesis		NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
CXCL9 and SFTPC	C-X-C motif chemokine ligand 9	surfactant protein C	Chemokine receptors bind chemokines G alpha (i) signalling events	Surfactant metabolism Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)				Pulmonary surfactant metabolism dysfunction (SMDP)
MT-CO1 and PRDX4	cytochrome c oxidase subunit I	peroxiredoxin 4	TP53 Regulates Metabolic Genes Respiratory electron transport	Neutrophil degranulation	Cholic Acid N-Formylmethionine Oxygen		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-CO1 and CLEC4G	cytochrome c oxidase subunit I	C-type lectin domain family 4 member G	TP53 Regulates Metabolic Genes Respiratory electron transport	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Cholic Acid N-Formylmethionine Oxygen		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-CO1 and SNCA	cytochrome c oxidase subunit I	synuclein alpha	TP53 Regulates Metabolic Genes Respiratory electron transport	Amyloid fiber formation	Cholic Acid N-Formylmethionine Oxygen	Resveratrol Copper	Leber optic atrophy; Leber hereditary optic atrophy (LHON)	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
MT-CO2 and RIDA	cytochrome c oxidase subunit II	reactive intermediate imine deaminase A homolog	TP53 Regulates Metabolic Genes Respiratory electron transport	Threonine catabolism	Cholic Acid N-Formylmethionine Talmapimod	Benzoic Acid
MT-CO2 and PSMA1	cytochrome c oxidase subunit II	proteasome 20S subunit alpha 1	TP53 Regulates Metabolic Genes Respiratory electron transport	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK - noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	Cholic Acid N-Formylmethionine Talmapimod	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
MT-CO2 and RAD21	cytochrome c oxidase subunit II	RAD21 cohesin complex component	TP53 Regulates Metabolic Genes Respiratory electron transport	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Cholic Acid N-Formylmethionine Talmapimod
MT-CO2 and YWHAE	cytochrome c oxidase subunit II	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	TP53 Regulates Metabolic Genes Respiratory electron transport	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs	Cholic Acid N-Formylmethionine Talmapimod	Fusicoccin Phenethyl Isothiocyanate		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
MT-CO3 and SNCA	cytochrome c oxidase III	synuclein alpha	TP53 Regulates Metabolic Genes Respiratory electron transport	Amyloid fiber formation	Cholic Acid N-Formylmethionine	Resveratrol Copper	Leber optic atrophy; Leber hereditary optic atrophy (LHON)	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
MT-CYB and MVP	cytochrome b	major vault protein	Respiratory electron transport	Neutrophil degranulation	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE 5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE FAMOXADONE METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE UBIQUINONE-2		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND1 and TST	NADH dehydrogenase, subunit 1 (complex I)	thiosulfate sulfurtransferase	Respiratory electron transport Complex I biogenesis	Sulfide oxidation to sulfate Degradation of cysteine and homocysteine	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate	S-Mercaptocysteine	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND1 and PAXIP1	NADH dehydrogenase, subunit 1 (complex I)	PAX interacting protein 1	Respiratory electron transport Complex I biogenesis	Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ)	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND1 and DHDDS	NADH dehydrogenase, subunit 1 (complex I)	dehydrodolichyl diphosphate synthase subunit	Respiratory electron transport Complex I biogenesis	Synthesis of Dolichyl-phosphate Defective DHDDS causes retinitis pigmentosa 59	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND1 and RPL13A	NADH dehydrogenase, subunit 1 (complex I)	ribosomal protein L13a	Respiratory electron transport Complex I biogenesis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate	Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Anisomycin Puromycin	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND1 and RPL6	NADH dehydrogenase, subunit 1 (complex I)	ribosomal protein L6	Respiratory electron transport Complex I biogenesis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND1 and SIRPA	NADH dehydrogenase, subunit 1 (complex I)	signal regulatory protein alpha	Respiratory electron transport Complex I biogenesis	Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate		Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND2 and SRC	MTND2	SRC proto-oncogene, non-receptor tyrosine kinase	Respiratory electron transport Complex I biogenesis	Signaling by ERBB2 Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GAB1 signalosome Downstream signal transduction Constitutive Signaling by Aberrant PI3K in Cancer Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Regulation of commissural axon pathfinding by SLIT and ROBO RAF activation MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PTK2 signaling InlA-mediated entry of Listeria monocytogenes into host cells Regulation of RUNX1 Expression and Activity RUNX2 regulates osteoblast differentiation Regulation of RUNX3 expression and activity Extra-nuclear estrogen signaling Activated NTRK2 signals through FYN Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K Long-term potentiation Signaling downstream of RAS mutants	NADH	Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN RU82129 PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric Acid RU81843 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A XL228 Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib Nintedanib	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
MT-ND2 and STK11	MTND2	serine/threonine kinase 11	Respiratory electron transport Complex I biogenesis	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	NADH		Leber optic atrophy; Leber hereditary optic atrophy (LHON)	Peutz-Jeghers syndrome Pancreatic cancer

Search Results for: Respiratory