SUMO2 and HDAC2

Number of citations of the paper that reports this interaction (PubMedID 19394292)
74

Data Source:
BioGRID (pull down)

		SUMO2	HDAC2
Description		small ubiquitin like modifier 2	histone deacetylase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PML Body	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Sin3 Complex NuRD Complex Protein-containing Complex ESC/E(Z) Complex Sin3-type Complex
	Molecular Function	Transcription Corepressor Binding RNA Binding Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Sequence-specific DNA Binding NF-kappaB Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Remodeling Maintenance Of Chromatin Silencing Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Response To Caffeine Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Response To Nicotine Response To Cocaine Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Positive Regulation Of Oligodendrocyte Differentiation Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Male Mating Behavior Cellular Response To Dopamine Negative Regulation Of Peptidyl-lysine Acetylation
Pathways		Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER	p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Factors involved in megakaryocyte development and platelet production
Drugs			Lovastatin Theophylline Valproic Acid Aminophylline Oxtriphylline Vorinostat Belinostat Pracinostat Romidepsin Panobinostat Tixocortol Mocetinostat
Diseases
GWAS		Gamma glutamyl transferase levels ( 29403010)	Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Metabolite levels ( 23823483)
Interacting Genes		179 interacting genes: ABRAXAS1 AHNAK ALAS1 ANAPC2 ANXA1 ATF7IP ATRX ATXN7 BABAM2 BAD BAZ1A BAZ1B BLM BRCC3 C18orf25 CAD CARS1 CCNE2 CENPC CHAF1A CHAF1B CHAMP1 CHD3 CHD4 CMTM6 CSNK2B CTNND1 CUL3 CUX1 DAXX DCD DDX17 DDX21 DDX3X DNM1L EEF1A1 EEF1G EGLN3 EME1 ENO1 EP300 ERCC4 EXOSC10 EXOSC9 FOS GATAD2B HDAC1 HDAC2 HDAC4 HDAC9 HIPK2 HNRNPF HNRNPH1 HNRNPK HOMEZ HP1BP3 HSF2 HSP90AB1 HSPA1A HSPA8 HSPA9 IPO5 JUN KALRN KDM1A KIF18B LAS1L LEF1 MAF1 MAST2 MDC1 MDN1 MKI67 MRE11 MSH2 MSX1 MTA1 MTA2 MUS81 MYB NBN NFE2L2 NOL9 NOP2 NUMA1 PARN PELP1 PFKM PHF5A PHF8 PIAS1 PIAS2 PIAS3 PIAS4 PML POGZ PRKDC RAD50 RAD51 RAD54L2 RANBP2 RANGAP1 RBBP4 RBBP7 RCOR1 RCOR2 RCOR3 RNF111 RNF168 RNF216 RNF4 RNF8 RPL3 RPL4 RUVBL1 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SIMC1 SLC22A2 SLX4IP SMCHD1 SOBP SOX10 SOX6 SP100 SSRP1 SUPT16H TDG TDP2 TEAD3 TEX10 TMPO TNIP1 TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TPR TRAF1 TRIM26 TRIM28 TRIM63 TRIML2 TUBA1B TUBB TUBB4B TUBB6 UBA2 UBE2I USP11 USP25 USP28 USP7 USPL1 VIM WRN XRCC5 XRCC6 ZBED1 ZBTB2 ZBTB25 ZBTB33 ZCCHC12 ZCCHC7 ZHX1 ZMAT3 ZMYM3 ZMYM4 ZMYM5 ZNF451 ZNF496	106 interacting genes: ANTXR1 APPL1 ARID4A AURKA BCL11A BRCA1 BRMS1 BRMS1L BUB3 CABIN1 CDC20 CDH1 CDKN1A CDYL CHD3 CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 FKBP3 FOXO3 FTCD FYN GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LAMA4 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MTA2 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA REV3L RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 STK25 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TNS4 TOP2A TOP2B TP53 TREML2 USP4 VHL YY1 ZBTB16 ZNF461
Entrez ID		6613	3066
HPRD ID		04332	05521
Ensembl ID		ENSG00000188612	ENSG00000196591
Uniprot IDs		A0A024R8S3 P61956	Q92769
PDB IDs		1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2N1W 2N9E 2RPQ 3UIN 3UIO 3ZO5 4BKG 4NPN 5D2M 5ELU 5EQL 5GHB 5GHC	3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O
Enriched GO Terms of Interacting Partners?
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