MARK4 and MAP2

Number of citations of the paper that reports this interaction (PubMedID 14594945)
42

Data Source:
HPRD (in vitro)

		MARK4	MAP2
Description		microtubule affinity regulating kinase 4	microtubule associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Neuron Projection	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Postsynaptic Density Dendrite Dendrite Cytoplasm Nuclear Periphery Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite CA3 Pyramidal Cell Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tau Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Cell Cycle Nervous System Development Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Regulation Of Centrosome Cycle Cell Division Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Axonogenesis Dendrite Development Central Nervous System Neuron Development Establishment Of Cell Polarity Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Dendrite Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of Cellular Protein Localization Negative Regulation Of Microtubule Binding Negative Regulation Of Microtubule Motor Activity
Pathways		Anchoring of the basal body to the plasma membrane
Drugs			Estramustine Paclitaxel Docetaxel
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil counts ( 27863252) Granulocyte count ( 27863252) Hematocrit ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 31504236 30980028) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196)
Interacting Genes		28 interacting genes: CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MTUS2 NEDD4 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ	26 interacting genes: ACSL3 ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 TUBA1A
Entrez ID		57787	4133
HPRD ID		09402	01140
Ensembl ID		ENSG00000007047	ENSG00000078018
Uniprot IDs		Q96L34	A0A024R3Y8 A0A024R3Z1 A0A024R409 P11137 Q6NYC5
PDB IDs		5ES1
Enriched GO Terms of Interacting Partners?
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