KMT2A and KAT8

Number of citations of the paper that reports this interaction (PubMedID 15960975)
269

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		KMT2A	KAT8
Description		lysine methyltransferase 2A	lysine acetyltransferase 8
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Histone Methyltransferase Complex MLL1 Complex	Histone Acetyltransferase Complex Kinetochore Nuclear Chromatin Nucleus Nucleoplasm Nuclear Matrix MLL1 Complex MSL Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific AT DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Unmethylated CpG Binding Lysine-acetylated Histone Binding	Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Transporter Activity Circadian Regulation Of Gene Expression Embryonic Hemopoiesis Histone H4-K16 Acetylation Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Protein-containing Complex Assembly Regulation Of Histone H3-K14 Acetylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of DNA Methylation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Cellular Response To Drug	Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis	HATs acetylate histones
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Metabolic syndrome ( 31589552)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059)
Interacting Genes		33 interacting genes: ASH2L AVP BMI1 CBX4 CREBBP CTNNB1 EXOSC5 FASLG H3-3A H3-4 H3C1 H3C14 HCFC1 HCFC2 INS KAT8 MEN1 MTM1 OXT PAF1 PLXNB1 PPIE PPP1R15A RBBP5 RDX RNF2 SBF1 SET SVIL TAF9 TASP1 TOP1 WDR5	12 interacting genes: ATM BAZ2A FOXP3 H4C1 KANSL1 KMT2A MSL3 PAF1 PLAU RNF2 TP53 TP53BP1
Entrez ID		4297	84148
HPRD ID		01162	11381
Ensembl ID		ENSG00000118058	ENSG00000103510
Uniprot IDs		Q03164	Q9H7Z6
PDB IDs		2AGH 2J2S 2JYI 2KKF 2KU7 2KYU 2LXS 2LXT 2MSR 2MTN 2W5Y 2W5Z 3EG6 3EMH 3LQH 3LQI 3LQJ 3P4F 3U85 3U88 4ESG 4GQ6 4NW3 5F5E 5F6L 5SVH 6EMQ 6KIU 6KIV 6KIX 6KIZ	2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR
Enriched GO Terms of Interacting Partners?
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