HES1 and LTBR

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HES1	LTBR
Description		hes family bHLH transcription factor 1	lymphotoxin beta receptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Golgi Apparatus Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding HLH Domain Binding Sequence-specific DNA Binding Chaperone Binding E-box Binding N-box Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Nervous System Development Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Adenohypophysis Development Cell Differentiation Lung Development Positive Regulation Of BMP Signaling Pathway Midbrain Development Pancreas Development Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of DNA Binding Regulation Of Fat Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Regulation Of JAK-STAT Cascade Positive Regulation Of JAK-STAT Cascade Cell Maturation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Inner Ear Receptor Cell Stereocilium Organization Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Protein-containing Complex Assembly Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Establishment Of Epithelial Cell Polarity Vascular Smooth Muscle Cell Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Cell Fate Determination Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation	Apoptotic Process Immune Response Signal Transduction Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Thyroid stimulating hormone levels ( 30367059)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 27182965 28928442)
Interacting Genes		35 interacting genes: APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY1 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NHLH2 NR4A1 NUDT3 PRKCA PTK2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB	14 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11
Entrez ID		3280	4055
HPRD ID		00770	02988
Ensembl ID		ENSG00000114315	ENSG00000111321
Uniprot IDs		Q14469	P36941
PDB IDs		2MH3	1RF3 4MXW
Enriched GO Terms of Interacting Partners?
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