CFH and PTX3

Number of citations of the paper that reports this interaction (PubMedID 19050261)
58

Data Source:
HPRD (in vitro)

		CFH	PTX3
Description		complement factor H	pentraxin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Protein Binding Heparin Binding Identical Protein Binding Heparan Sulfate Proteoglycan Binding	Complement Component C1q Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	Complement Activation Complement Activation, Alternative Pathway Viral Process Regulation Of Complement Activation Regulation Of Complement-dependent Cytotoxicity	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Regulation of Complement cascade	Neutrophil degranulation
Drugs		Zinc Copper
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576 29875488 28240269) Chronic central serous retinopathy ( 30480742 30073298) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Exudative age-related macular degeneration ( 25629512) Fuchs's corneal dystrophy ( 28358029) Matrix metalloproteinase-8 levels ( 29212897) Meningococcal disease ( 20694013) Neovascular age-related macular degeneration ( 28703135) Nephropathy ( 21399633) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Serum C3d:C3 ratio (systemic complement activation) ( 29398083) Sub-foveal choroidal thickness ( 29844195) Systemic lupus erythematosus ( 28714469)	Body mass index ( 26426971)
Interacting Genes		16 interacting genes: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16	15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A
Entrez ID		3075	5806
HPRD ID		00601	03928
Ensembl ID		ENSG00000000971	ENSG00000163661
Uniprot IDs		A0A024R962 A0A0D9SG88 P08603	P26022
PDB IDs		1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT 4ZH1 5NBQ 5O32 5O35 5WTB 6ATG
Enriched GO Terms of Interacting Partners?
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