H2AC1 and TLE3

Number of citations of the paper that reports this interaction (PubMedID 28689657)
7

Data Source:
BioGRID (unspecified method)

		H2AC1	TLE3
Description		H2A clustered histone 1	TLE family member 3, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleosome Nuclear Chromatin Nucleus Extracellular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Beta-catenin-TCF Complex
	Molecular Function	DNA Binding Protein Heterodimerization Activity	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Chromatin Organization Chromatin Silencing	Regulation Of Transcription, DNA-templated Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nucleic Acid-templated Transcription Beta-catenin-TCF Complex Assembly
Pathways		HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 31562340) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 30046033) Pulmonary function ( 23932459) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Schizophrenia ( 25056061 29483656 30285260) Serum total protein level ( 29403010) Triglyceride levels ( 29403010) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		5 interacting genes: ANP32B HDAC1 HDAC2 HDAC3 TLE3	19 interacting genes: APP BIRC5 BMP3 FBXO7 FEM1B FOXG1 H2AC1 H3C1 H4C1 HINFP NDRG1 NOTCH1 PIN1 RPL4 SIX3 SRP14 TAOK2 TCF7L2 XIAP
Entrez ID		221613	7090
HPRD ID		13653	02558
Ensembl ID		ENSG00000164508	ENSG00000140332
Uniprot IDs		Q96QV6	B3KUA2 F5H7D6 H0YL70 Q04726 Q6PRX3
PDB IDs		5GSU 5GT0
Enriched GO Terms of Interacting Partners?
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