NOG

Description		noggin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Cytokine Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Endoderm Formation Mesoderm Formation Epithelial To Mesenchymal Transition Neural Plate Morphogenesis Neural Tube Closure Membranous Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Ventricular Compact Myocardium Morphogenesis Nervous System Development Motor Neuron Axon Guidance Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Spinal Cord Development Cell Differentiation In Hindbrain Pituitary Gland Development Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Wound Healing Middle Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Notochord Morphogenesis Embryonic Skeletal System Development Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Atrial Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Limb Development Embryonic Skeletal Joint Morphogenesis Negative Regulation Of Cytokine Activity Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Lung Morphogenesis Prostatic Bud Formation Ureteric Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Cartilage Development Somite Development BMP Signaling Pathway Involved In Heart Development Heart Trabecula Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glomerulus Development Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by BMP
Drugs
Diseases		Brachydactyly, including: type A; type B; type D; type E Tarsal-carpal coalition syndrome Stapes ankylosis with broad thumb and toes Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 29875488) Celiac disease ( 23936387) Cleft lip with or without cleft palate ( 28054174) Height ( 20881960 31562340 18391951) Metabolite levels ( 23823483) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: BMP2 BMP4 BMP5 BMP7
Entrez ID		9241
HPRD ID		04291
Ensembl ID		ENSG00000183691
Uniprot IDs		Q13253
PDB IDs		1M4U
Enriched GO Terms of Interacting Partners?
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