TIMP3

Description		TIMP metallopeptidase inhibitor 3
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Platelet Degranulation Visual Perception Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Organic Substance Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Metalloendopeptidase Activity
Pathways		Platelet degranulation
Drugs		Pimagedine
Diseases		Sorsby fundus dystrophy
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Alzheimer's disease progression score ( 29860282) Blood protein levels ( 30072576 28240269) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)
Interacting Genes		8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9
Entrez ID		7078
HPRD ID		01785
Ensembl ID		ENSG00000100234
Uniprot IDs		P35625
PDB IDs		3CKI
Enriched GO Terms of Interacting Partners?
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