TEK

Description		TEK receptor tyrosine kinase
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GO Annotations	Cellular Component	Stress Fiber Extracellular Region Cytoplasm Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Centriolar Satellite Receptor Complex Membrane Raft
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Growth Factor Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	MAPK Cascade Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Heart Development Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Glomerulus Vasculature Development Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Tie2 Signaling Tie2 Signaling RAF/MAP kinase cascade
Drugs		Ampicillin Vandetanib N-{4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]PHENYL}-3-(TRIFLUOROMETHYL)BENZAMIDE Regorafenib Ponatinib
Diseases		Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Adult asthma ( 27611488) Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Asthma ( 27611488) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Cognitive decline (age-related) ( 28078323) Coronary artery disease ( 29212778)
Interacting Genes		25 interacting genes: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP CAV1 DOK2 DOK4 DUSP18 GRB14 GRB2 GRB7 IKBKG ILKAP PIK3R1 PTPN11 PTPRB PTPRR SHC1 SOCS1 STAT5A STAT5B STYX TIE1 TNIP2
Entrez ID		7010
HPRD ID		02571
Ensembl ID		ENSG00000120156
Uniprot IDs		Q02763 Q59HG2
PDB IDs		1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V 4X3J 5MYA 5MYB 5UTK 6MWE
Enriched GO Terms of Interacting Partners?
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