SCN2A

Description		sodium voltage-gated channel alpha subunit 2
Image
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Cation Channel Activity
	Biological Process	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Valproic Acid Lamotrigine Propofol Zonisamide Tetrodotoxin Brivaracetam Metergoline
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Bipolar disorder ( 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		6326
HPRD ID		03133
Ensembl ID		ENSG00000136531
Uniprot IDs		Q99250
PDB IDs		2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
Tagcloud ?