PTGS2

Description		prostaglandin-endoperoxide synthase 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Caveola Protein-containing Complex Neuron Projection
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Transferase Activity Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Prostaglandin Biosynthetic Process Angiogenesis Inflammatory Response Response To Oxidative Stress Embryo Implantation Aging Learning Memory Regulation Of Blood Pressure Negative Regulation Of Cell Proliferation Response To Fructose Response To Manganese Ion Response To Lithium Ion Positive Regulation Of Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cyclooxygenase Pathway Lipoxygenase Pathway Bone Mineralization Ovulation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Synaptic Plasticity Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin D NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Cellular Response To Heat Response To Tumor Necrosis Factor Cellular Response To UV Maintenance Of Permeability Of Blood-brain Barrier Positive Regulation Of Protein Import Into Nucleus Hair Cycle Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Cell Cycle Positive Regulation Of Vasoconstriction Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Decidualization Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Inflammatory Response Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of Calcium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Oxidation-reduction Process Response To Fatty Acid Cellular Response To Mechanical Stimulus Cellular Response To Lead Ion Cellular Response To ATP Cellular Response To Hypoxia Cellular Response To Non-ionic Osmotic Stress Cellular Response To Fluid Shear Stress Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Negative Regulation Of Blood Vessel Diameter Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Angiotensin
Pathways		Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs		Dihomo-gamma-linolenic acid Icosapent Aminosalicylic Acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic Acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic Acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Dexibuprofen Firocoxib Alclofenac Acemetacin
Diseases		Esophageal cancer Cholangiocarcinoma Penile cancer
GWAS		Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
Entrez ID		5743
HPRD ID		02599
Ensembl ID		ENSG00000073756
Uniprot IDs		P35354
PDB IDs		1V0X 5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
Enriched GO Terms of Interacting Partners?
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