PLEK

Description		pleckstrin
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane
	Molecular Function	Protein Kinase C Binding Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Platelet Degranulation Vesicle Docking Involved In Exocytosis Integrin-mediated Signaling Pathway Positive Regulation Of Platelet Activation Negative Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Inositol-polyphosphate 5-phosphatase Activity Cell Projection Organization Positive Regulation Of Actin Filament Depolymerization Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Cortical Actin Cytoskeleton Organization Ruffle Organization Actin Cytoskeleton Reorganization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Integrin Activation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Diameter Thrombin-activated Receptor Signaling Pathway Platelet Aggregation Protein Kinase C Signaling Protein Secretion By Platelet
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Anger ( 24489884) Celiac disease ( 20190752) Lymphocyte counts ( 27863252) Metabolite levels ( 19043545) Multiple sclerosis ( 31604244 22190364 24076602 21833088) Plateletcrit ( 27863252) Venous thromboembolism ( 31420334)
Interacting Genes		4 interacting genes: ACVR1 INPP5A RHOU TGFBR1
Entrez ID		5341
HPRD ID		15935
Ensembl ID		ENSG00000115956
Uniprot IDs		P08567
PDB IDs		1PLS 1W4M 1X05 1XX0 1ZM0 2CSO 2I5C 2I5F
Enriched GO Terms of Interacting Partners?
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