PKLR

Description		pyruvate kinase L/R
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Pyruvate Kinase Activity ATP Binding Kinase Activity Potassium Ion Binding
	Biological Process	Response To Hypoxia Glycolytic Process ATP Biosynthetic Process Response To Heat Response To Glucose Response To Lithium Ion Cellular Response To Insulin Stimulus Response To ATP Pyruvate Biosynthetic Process Response To CAMP Canonical Glycolysis Cellular Response To Epinephrine Stimulus
Pathways
Drugs		Pyruvic acid 2-Phosphoglycolic Acid beta-D-fructofuranose 1,6-bisphosphate
Diseases		Pyruvate kinase (PK) deficiency, including: Red cell pyruvate kinase (PK) deficiency; Pyruvate kinase hyperactivity
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Crohn's disease ( 28067908) Hemoglobin levels ( 24777453) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Major depressive disorder ( 29317602) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Urate levels ( 23263486)
Interacting Genes		3 interacting genes: CLEC4G MYOC PCNA
Entrez ID		5313
HPRD ID		11841
Ensembl ID		ENSG00000143627
Uniprot IDs		P30613
PDB IDs		2VGB 2VGF 2VGG 2VGI 4IMA 4IP7 6NN4 6NN5 6NN7 6NN8
Enriched GO Terms of Interacting Partners?
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