SIRT7

Description		sirtuin 7
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Nucleolus Organizer Region Cytoplasm Site Of Double-strand Break
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Deacetylase Activity NAD-dependent Protein Deacetylase Activity Protein-succinyllysine Desuccinylase Activity Metal Ion Binding Protein-glutaryllysine Deglutarylase Activity NAD+ Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Gluconeogenesis DNA Repair Regulation Of DNA Repair Protein Deacetylation Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription Involved In Exit From Mitosis Synapsis RRNA Transcription Negative Regulation Of Transposition Regulation Of Mitochondrion Organization Histone Modification Negative Regulation Of Protein Ubiquitination Peptidyl-lysine Desuccinylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Export From Nucleus Protein Deglutarylation Peptidyl-lysine Deglutarylation Histone H3 Deacetylation Histone H4 Deacetylation Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Histone Glutamine Methylation Positive Regulation Of RRNA Processing Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS
Interacting Genes		9 interacting genes: APP DDB1 H2AC20 H2BC21 H3C1 H4C1 MAGED1 USP7 WDR77
Entrez ID		51547
HPRD ID		12094
Ensembl ID		ENSG00000187531
Uniprot IDs		Q9NRC8
PDB IDs		5IQZ 6G0S
Enriched GO Terms of Interacting Partners?
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