G6PD

Description		glucose-6-phosphate dehydrogenase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Membrane Centriolar Satellite Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Glucose-6-phosphate Dehydrogenase Activity Protein Binding Glucose Binding Identical Protein Binding Protein Homodimerization Activity NADP Binding
	Biological Process	Glucose Metabolic Process Pentose-phosphate Shunt Lipid Metabolic Process Cholesterol Biosynthetic Process NADP Metabolic Process NADPH Regeneration Glutathione Metabolic Process Pentose-phosphate Shunt, Oxidative Branch Response To Iron(III) Ion Negative Regulation Of Protein Glutathionylation Response To Organic Cyclic Compound Pentose Biosynthetic Process Substantia Nigra Development Response To Food Cellular Response To Oxidative Stress Erythrocyte Maturation Regulation Of Neuron Apoptotic Process Response To Ethanol Ribose Phosphate Biosynthetic Process Glucose 6-phosphate Metabolic Process Oxidation-reduction Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		TP53 Regulates Metabolic Genes Pentose phosphate pathway
Drugs		Glycolic acid 2'-Monophosphoadenosine 5'-Diphosphoribose 16-Bromoepiandrosterone Artenimol
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Bilirubin levels ( 19419973) Glycated hemoglobin levels ( 31213470 28898252) Hemoglobin levels ( 26366553) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 28453575) Mean corpuscular volume ( 28453575) Red blood cell count ( 28453575) Red blood cell traits ( 23446634 23696099) Red cell distribution width ( 28453575)
Interacting Genes		2 interacting genes: PAK4 SUMO4
Entrez ID		2539
HPRD ID		02377
Ensembl ID		ENSG00000160211
Uniprot IDs		A0A384NL00 P11413
PDB IDs		1QKI 2BH9 2BHL 5UKW 6E07 6E08
Enriched GO Terms of Interacting Partners?
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