DDAH1

Description		dimethylarginine dimethylaminohydrolase 1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Dimethylargininase Activity Amino Acid Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Metal Ion Binding
	Biological Process	Citrulline Metabolic Process Regulation Of Systemic Arterial Blood Pressure Arginine Metabolic Process Arginine Catabolic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cell Proliferation Negative Regulation Of Vascular Permeability Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Cellular Response To Hypoxia
Pathways		eNOS activation
Drugs		L-Citrulline
Diseases
GWAS		Asymmetrical dimethylarginine levels ( 25245031 24159190) Height ( 31562340) Multiple sclerosis ( 24076602 21833088) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Pulse pressure ( 30224653) Serum dimethylarginine levels (asymmetric/symetric ratio) ( 24159190) Symmetrical dimethylarginine levels ( 24159190) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		1 interacting genes: CALM1
Entrez ID		23576
HPRD ID		09203
Ensembl ID		ENSG00000153904
Uniprot IDs		B2R644 B4DGT0 B4DYP1 B4E3V1 O94760
PDB IDs		2JAI 2JAJ 3I2E 3I4A 3P8E 3P8P 6DGE
Enriched GO Terms of Interacting Partners?
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