GLIS3

Description		GLIS family zinc finger 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM)
GWAS		Alzheimer's disease biomarkers ( 23562540) Blood sugar levels ( 29403010) Central corneal thickness ( 29760442) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Glaucoma (primary angle closure) ( 27064256) Height ( 28552196) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Homeostasis model assessment of beta-cell function ( 20081858) Intraocular pressure ( 29617998 29785010 30054594 30591961 29235454) Low high density lipoprotein cholesterol levels ( 26879886) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Methotrexate phramacokinetics (acute lymphoblastic leukemia) ( 19901119) Neurociticism ( 29500382) Nicotine dependence ( 28440896) Offspring birth weight ( 31043758) Osteoarthritis of the hip or knee ( 29436472) Osteoarthritis of the hip or knee (with total joint replacement) ( 29436472) Peak expiratory flow ( 30804560) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Red blood cell count ( 27863252) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spontaneous preterm birth (preterm delivery) ( 25599974) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653) Thyroid hormone levels ( 23408906) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 1 diabetes ( 25751624 19430480 18840781) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 22961080 22158537 30718926 28869590)
Interacting Genes		3 interacting genes: CLNK ITCH SUFU
Entrez ID		169792
HPRD ID		13582
Ensembl ID		ENSG00000107249
Uniprot IDs		A0A0S2Z689 Q1PHJ8 Q8NEA6
PDB IDs
Enriched GO Terms of Interacting Partners?
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