CYP11A1

Description		cytochrome P450 family 11 subfamily A member 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Iron Ion Binding Protein Binding Cholesterol Monooxygenase (side-chain-cleaving) Activity Heme Binding
	Biological Process	C21-steroid Hormone Biosynthetic Process Glucocorticoid Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Cortisol Metabolic Process Vitamin D Metabolic Process Oxidation-reduction Process Cellular Response To Peptide Hormone Stimulus
Pathways		Pregnenolone biosynthesis Endogenous sterols Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Drugs		Aminoglutethimide
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Craniofacial microsomia ( 26853712) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		6 interacting genes: CYP11B2 ETFA FDX1 SMAD2 SMAD3 SMAD9
Entrez ID		1583
HPRD ID		00326
Ensembl ID		ENSG00000140459
Uniprot IDs		A0A0S2Z3R3 P05108
PDB IDs		3N9Y 3N9Z 3NA0 3NA1
Enriched GO Terms of Interacting Partners?
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