CENPE

Description		centromere protein E
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Cell Nucleus Nucleoplasm Chromosome Kinetochore Microtubule Cytosol Kinesin Complex Microtubule Microtubule Cytoskeleton Membrane Midbody Spindle Midzone Mitotic Spindle Midzone
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity Kinetochore Binding
	Biological Process	Mitotic Cell Cycle Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Multicellular Organism Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs		GSK-923295
Diseases
GWAS		Chlamydia trachomatis seropositivity ( 29967566) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 25877299 28604728 28604732 23666240)
Interacting Genes		11 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC
Entrez ID		1062
HPRD ID		00316
Ensembl ID		ENSG00000138778
Uniprot IDs		Q02224
PDB IDs		1T5C 5JVP
Enriched GO Terms of Interacting Partners?
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